7 research outputs found
Psoriasis induced by firstâline pembrolizumab in metastatic nonâsmall cell lung cancer: a case report
: Therapeutic options for non-small cell lung cancer (NSCLC) have changed with the introduction of immune checkpoint inhibitors. Immunotherapy is generally well tolerated, but can also be associated with severe adverse events, such as the development of new autoimmune diseases. In patients without a history of autoimmune diseases, psoriasis caused by immunotherapy treatment is rarely described in the literature. The present study describes the case of a 68-year-old man with metastatic NSCLC that started chemoimmunotherapy with carboplatin plus pemetrexed plus pembrolizumab. After two cycles of therapy, the patient developed a G3 maculopapular rash. Biopsy confirmed psoriasis and pembrolizumab treatment was discontinued. At the last follow up, the patient was still on maintenance therapy with pemetrexed alone, which is well tolerated. Psoriasis has rarely been reported as an immune-related adverse event. Although the patient had to stop the immunotherapy treatment, the patient is still exhibiting a response to it. Notably, it has previously been described how skin toxicities are associated with a better outcome. Other studies need to be conducted to identify the risk and predictive factors associated with severe immune adverse events and objective response
Massive facial edema and airway obstruction secondary to acute postoperative sialadenitis or "anesthesia mumps": a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Erythroplasia of Queyrat treated with methyl aminolevulinate-photodynamic therapy
Erythroplasia of Queyrat (EQ) is a rare disease involving the mucosal and transitional surfaces of the penis. Effective treatment is necessary to minimize progression to squamous cell carcinoma. The standard therapy for EQ, partial or radical penectomy, is invasive; photodynamic therapy (PDT) may be an effective, non-surgical tissue-sparing option. We report the case of a 67-year-old patient with long-standing EQ who was successfully treated with methyl aminolevulinate-PDT (MAL-PDT). A complete clinical response, confirmed by incisional biopsy, was achieved after five sessions of every-other-week treatment. The patient experienced moderate edema, erythema and pain within 5-7 days after the treatment, without urination problems. Our experience and a review of the published literature suggest that MAL-PDT may represent a valuable treatment option for selected cases of histopathologically-confirmed EQ
Diagnosing the Less Common Skin Tumors Clinical Appearance and Dermoscopy Correlation
Many texts deal with how to diagnose the straightforward melanomas of the skin, but there are many less common skin tumors that a clinician needs to be aware of because these are still likely to be encountered at some point in a clinical setting and many of them have serious implications. This highly illustrated text from an internationally acclaimed researcher provides a reliable guide to how to proceed with diagnosis of these more challenging entities.
Contents: Tumors of the Epidermis: Nevoid basal cell carcinoma syndrome * Fibroepithelioma of Pinkus * Basosquamous carcinoma * Verrucous carcinoma * Sarcomatoid squamous cell carcinoma * Lentigines, Nevi, and Melanoma: Atypical Spitz nevus (tumor) * Halo Spitz nevus * Desmoplastic nevus * Pigmented epithelioid melanocytoma * Animal-type melanoma * Nevoid melanoma * Balloon cell melanoma * Desmoplastic melanoma * Special site melanoma (mucosal, acral) * Tumors of Cutaneous Appendages: Trichoadenoma * Trichoepithelioma and Brooke-Spiegler syndrome * Desmoplastic trichoepithelioma * Trichoblastoma * Tumors of the follicular infundibulum * Tricholemmoma and tricholemmal carcinoma and Cowden syndrome * Pilomatrixoma * Fibrofolliculoma/trichodiscoma and BirtâHogg-Dubè syndrome * Sebaceous tumors *Syringocystadenoma papilliferum * Hidradenoma * Cylindroma and familial cylindromatosis and Brooke-Spiegler syndrome * Spiradenoma * Mammary and extramammary Pagetâs disease * Syringoma * Eccrine poroma and eccrine porocarcinoma * Mesenchymal Tumors: Dermatofibrosarcoma protuberans * Atypical fibroxanthoma * Malignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma) * Other Uncommon Tumors: Merkel cell carcinoma * Kaposiâs sarcoma * Angiosarcoma * Retiform hemangioendotheliom